Understanding calcium signaling in health and disease
Ca2+ signaling Networks in Health and Disease
This study is looking at how certain proteins help control calcium signals in our cells, which are important for things like movement and energy, to better understand how problems with these signals can lead to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11001941 on NIH RePORTER |
What this research studies
This research investigates how calcium channels in cells are constructed, activated, and regulated, and how their dysfunction can lead to diseases. By using animal models, the study aims to uncover the roles of specific calcium signaling proteins, such as ORAI and STIM, in controlling vital physiological functions. The research focuses on how these calcium signals affect processes like cell migration, secretion, and energy production, which are crucial for maintaining health. Through this work, the researchers hope to provide insights into the mechanisms behind various diseases linked to calcium signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to calcium signaling abnormalities, such as certain cardiovascular diseases.
Not a fit: Patients with conditions unrelated to calcium signaling or those who do not have any cardiovascular disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to calcium signaling dysfunction.
How similar studies have performed: Other research has shown promising results in understanding calcium signaling pathways, indicating that this approach has potential for significant advancements.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Trebak, Mohamed — University of Pittsburgh at Pittsburgh
- Study coordinator: Trebak, Mohamed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.