Understanding Calcium Pyrophosphate Deposition Arthritis
Molecular pathways of calcium pyrophosphate deposition disease
This project aims to understand the causes of calcium pyrophosphate deposition arthritis, especially in families, to find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11082981 on NIH RePORTER |
What this research studies
Calcium pyrophosphate deposition arthritis, or CPDD, happens when tiny crystals form in your joint cartilage, causing pain and stiffness. While it often affects older adults, some families experience it much earlier in life. By studying these familial cases, we hope to uncover the specific changes in the body that lead to CPDD. Our work focuses on a particular genetic change that seems to increase bone breakdown and may contribute to crystal formation, which could open doors to new treatments.
Who could benefit from this research
Good fit: Patients with calcium pyrophosphate deposition arthritis, particularly those with early-onset or familial forms, could potentially benefit from future treatments developed from this research.
Not a fit: Patients without calcium pyrophosphate deposition arthritis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new treatments for calcium pyrophosphate deposition arthritis, which currently has no specific cure.
How similar studies have performed: Preliminary findings have identified a specific genetic mutation linked to early-onset CPDD and its effects in animal models, suggesting a promising direction for this innovative hypothesis.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Rosenthal, Ann K — Medical College of Wisconsin
- Study coordinator: Rosenthal, Ann K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.