Understanding Calcium Channels TRPV6 and TRPV5
Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5
This work explores how two important calcium channels, TRPV6 and TRPV5, are controlled in the body, especially their connection to conditions like chronic pancreatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11120869 on NIH RePORTER |
What this research studies
Our bodies have special channels called TRPV6 and TRPV5 that help manage calcium levels in cells, particularly in areas like the pancreas. These channels are always active, and their function is carefully balanced by natural activators and inhibitors. We are learning how these channels bind to certain molecules and how their structure changes, which helps us understand how they work. This knowledge is important because changes in TRPV6, for example, have been linked to chronic pancreatitis, where calcium regulation goes awry.
Who could benefit from this research
Good fit: Patients with chronic pancreatitis or other conditions related to calcium regulation might find future developments from this research relevant to their health.
Not a fit: Patients without conditions related to calcium channel function, particularly TRPV5 or TRPV6, may not directly benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to control calcium levels in cells, potentially offering new treatments or prevention strategies for conditions like chronic pancreatitis.
How similar studies have performed: Previous work has successfully identified binding sites and structures of these channels, and new imaging techniques are providing consistent insights into their function.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Rohacs, Tibor — Rutgers Biomedical and Health Sciences
- Study coordinator: Rohacs, Tibor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.