Understanding calcium channels in the Toxoplasma gondii parasite
Official title: Divergent Calcium Channels of the Apicomplexan parasite Toxoplasma gondii
Funded at University of Georgia · NIH-11012266 · Data updated 2026-11-12
This study looks at how calcium helps the Toxoplasma gondii parasite grow and spread, especially in people with weakened immune systems, and aims to find new ways to treat infections caused by this parasite.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | February 7, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $582,006 |
| NIH project number | 5R01AI174600-03 |
| Project ID | NIH-11012266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are immunocompromised, such as those living with HIV/AIDS, organ transplant recipients, or pregnant women.
✕Less likely to help
Patients who are not immunocompromised or do not have a risk of Toxoplasma gondii infection may not benefit from this research.
What this research studies
This research investigates how calcium ions influence the life cycle of the Toxoplasma gondii parasite, which can cause serious infections in immunocompromised individuals. By exploring the calcium channels in this parasite, the study aims to uncover the mechanisms that allow it to thrive and spread within host cells. The research involves detailed biochemical analyses to identify the specific molecules that initiate calcium signaling in T. gondii, which is crucial for its virulence. The findings could lead to new strategies for treating infections caused by this parasite.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for infections caused by Toxoplasma gondii, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown that targeting calcium signaling pathways can be effective in treating other parasitic infections, suggesting potential for success in this area as well.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Moreno, Silvia N — University of Georgia
- Study coordinator: Moreno, Silvia N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.