Understanding calcium balance and cell health in sepsis
Administrative Supplement: Calcium homeostasis and cellular fitness in sepsis
This study looks at how sepsis impacts calcium levels and the health of cells in patients, especially focusing on the tiny powerhouses in our cells called mitochondria, to better understand why some people have ongoing health problems after recovering from sepsis and to find new ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11094539 on NIH RePORTER |
What this research studies
This research investigates how sepsis affects calcium levels and cellular health in patients. It focuses on the changes in mitochondria, the energy-producing structures in cells, during and after sepsis. By studying these changes, the research aims to uncover the mechanisms that lead to long-term health issues in sepsis survivors. The approach includes examining calcium signaling and its role in cellular responses to stress, which could help identify new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced sepsis and are recovering from it.
Not a fit: Patients who have not had sepsis or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and reduce long-term health complications for sepsis survivors.
How similar studies have performed: Previous research has shown promising results in understanding cellular responses to sepsis, but this specific focus on calcium homeostasis is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Rosengart, Matthew Randall — Washington University
- Study coordinator: Rosengart, Matthew Randall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.