Understanding Calcium and Cell Health in Sepsis Recovery
Calcium homeostasis and cellular fitness in sepsis
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11170737
This project explores how changes in cell calcium levels affect long-term health problems experienced by people recovering from sepsis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11170737 on ClinicalTrials.gov |
What this research studies
Sepsis is a severe illness that can lead to lasting health issues like memory problems and a higher risk of hospital readmission. We believe that early during sepsis, cells in the body change how they handle calcium and energy, which might protect them in the short term but cause long-term health problems. Our team has spent years learning how cells manage calcium and energy to stay healthy. This work aims to uncover the specific ways these cellular changes contribute to the ongoing health challenges faced by sepsis survivors.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying biological causes of long-term health issues after sepsis.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new ways to prevent or treat the long-term health complications that many sepsis survivors experience.
How similar studies have performed: This project builds upon nearly two decades of the lab's prior work on calcium-dependent mechanisms in sepsis, suggesting a foundation of previous findings.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSENGART, MATTHEW RANDALL — WASHINGTON UNIVERSITY
- Study coordinator: ROSENGART, MATTHEW RANDALL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.