Understanding C3 Glomerulopathy (Bright Disease)
C3 Glomerulopathy -- A Collaborative Study
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11234328
This project looks for genetic changes and immune targets that drive C3 glomerulopathy in people with Bright disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11234328 on ClinicalTrials.gov |
What this research studies
From a patient's point of view, researchers will collect clinical information and biological samples such as blood and kidney biopsy tissue to study C3G. They will analyze genes to find inherited or acquired variations linked to disease. They will map where autoantibodies bind to complement proteins to understand how the immune system damages the kidney. The team will also develop laboratory tools or tests to better track disease behavior and recurrence after transplant.
Who could benefit from this research
Good fit: People of any age diagnosed with C3 glomerulopathy (including dense deposit disease or C3 glomerulonephritis) who can provide consent for blood and biopsy samples and clinical follow-up are the ideal candidates.
Not a fit: People without C3 glomerulopathy or those unwilling to provide samples or clinical data are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could improve diagnosis, predict disease course, and point to more targeted treatments that reduce the risk of kidney failure or post-transplant recurrence.
How similar studies have performed: Previous studies have found complement gene variants and disease-associated autoantibodies in C3G, but comprehensive genetic profiling combined with detailed epitope mapping remains relatively novel.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, RICHARD J.H. — UNIVERSITY OF IOWA
- Study coordinator: SMITH, RICHARD J.H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bright Disease