Understanding Breathing and Autonomic Control in Sudden Infant Death Syndrome (SIDS)
Central & Peripheral Mechanisms of Respiratory & Autonomic Control Dysfunction in a Novel Model of SIDS: Predictive Biomarkers and the Role of the Extracellular Matrix
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11158571
This research aims to better understand why some infants are vulnerable to Sudden Infant Death Syndrome (SIDS) by looking at how their breathing and other automatic body functions are controlled.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11158571 on ClinicalTrials.gov |
What this research studies
Our bodies have automatic systems that control vital functions like breathing and heart rate, and problems with these systems are linked to SIDS. This project uses a new animal model that closely mimics the conditions seen in SIDS, including brain changes and issues with how the body senses oxygen levels. By studying this model, we hope to uncover the specific brainstem abnormalities that contribute to SIDS. We are particularly interested in how signals from the carotid body, which monitors oxygen, affect the brainstem and lead to these changes. This work could help us identify early warning signs and develop strategies to prevent SIDS.
Who could benefit from this research
Good fit: This foundational research does not directly involve human participants but aims to benefit infants at risk for SIDS in the future.
Not a fit: Infants who are not at risk for SIDS or those beyond infancy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to predict which infants are at risk for SIDS and potentially develop interventions to prevent these tragic deaths.
How similar studies have performed: While animal models have been crucial in SIDS research, this project utilizes a novel model that more accurately reflects the key features of SIDS, offering a new avenue for discovery.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACFARLANE, PETER — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: MACFARLANE, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.