Understanding Brainstem Changes in Sudden Infant Death Syndrome (SIDS)
Brainstem microRNA dysregulation in the pathogenesis of sudden infant death syndrome (SIDS)
This project looks at tiny genetic regulators in the brainstem to understand why some infants are vulnerable to Sudden Infant Death Syndrome (SIDS).
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11139514 on NIH RePORTER |
What this research studies
Sudden Infant Death Syndrome (SIDS) remains a leading cause of infant mortality, and we believe biological differences in the brainstem, particularly in the serotonin system, play a role. This work focuses on small genetic molecules called microRNAs, which are important for brain development and function. We found specific microRNAs that are different in infants who died from SIDS compared to healthy infants. By understanding how these microRNAs affect brainstem function, we hope to uncover new insights into SIDS.
Who could benefit from this research
Good fit: This foundational research does not involve patient participation, but future studies building on this work may seek infants at risk for SIDS or their biological samples.
Not a fit: Infants who are not at risk for SIDS or those whose families are not interested in contributing to research on SIDS mechanisms would not directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the biological causes of SIDS, potentially paving the way for future prevention strategies or ways to identify at-risk infants.
How similar studies have performed: While microRNA biology is a rapidly emerging field with clear evidence of its role in brain function, this specific investigation into miR-34a-5p and miR-122-5p in SIDS brainstems is a novel and focused approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Haynes, Robin Lynn — Boston Children's Hospital
- Study coordinator: Haynes, Robin Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.