Understanding brain tumors caused by specific genetic mutations
Official title: Modeling IDH Mutant Gliomas by Genetic Engineering of Brain Organoid
Funded at Birmingham VA Medical Center · NIH-10951520 · Data updated 2026-11-12
This study is looking at how certain gene changes in brain tumors called gliomas affect their growth, using special lab-grown brain models to find new ways to treat these tumors, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006107-02 |
| Project ID | NIH-10951520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with gliomas, particularly those with IDH mutations.
✕Less likely to help
Patients with gliomas that do not have IDH mutations may not benefit from this research.
What this research studies
This research investigates the mechanisms behind gliomas, a type of brain tumor, particularly focusing on mutations in the IDH1 and IDH2 genes. By using brain organoids derived from human pluripotent stem cells, the study aims to create a model that mimics the human brain environment, allowing researchers to explore how these mutations contribute to tumor development. The goal is to identify new therapeutic targets that could lead to better treatments for gliomas. Patients may benefit from insights gained through this research, which could inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for gliomas, improving outcomes for patients with this challenging condition.
How similar studies have gone: Previous research has shown promise in using organoid models to study various cancers, suggesting that this approach could yield valuable insights into glioma biology.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Han, Xiaosi — Birmingham VA Medical Center
- Study coordinator: Han, Xiaosi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.