Understanding Brain Swelling and Activity After Traumatic Brain Injury
The dynamic balance between neuronal volume and chloride handling in network excitability after traumatic brain injury
This project explores how brain swelling affects brain cell activity after a head injury, aiming to find better ways to help patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11166474 on NIH RePORTER |
What this research studies
Traumatic brain injury (TBI) often leads to brain swelling, which is a major cause of serious problems and even death. Current treatments for this swelling have not been as successful as we hoped, partly because we don't fully understand how it works. This project looks closely at how brain cells swell after a TBI and how this swelling changes the way brain cells communicate. We are particularly interested in how these changes affect brain activity after both mild and severe injuries. By understanding these fundamental processes, we hope to uncover new targets for treatment.
Who could benefit from this research
Good fit: Patients who have experienced a traumatic brain injury and suffer from brain swelling or related neurological issues could potentially benefit from future treatments developed from this research.
Not a fit: Patients without a traumatic brain injury or those whose brain swelling is due to other causes may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for brain swelling and related issues after traumatic brain injury, improving patient outcomes.
How similar studies have performed: While current treatments for TBI-related brain swelling have limited success, this project builds on recent unexpected findings about the link between neuronal swelling and brain cell activity, suggesting a novel direction.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Pokam, Punam Adhik — Texas A&m University Health Science Ctr
- Study coordinator: Pokam, Punam Adhik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.