Understanding brain signals related to fentanyl use in humans
Characterizing brain dynamic biomarkers of fentanyl using intracranial and high-density electroencephalogram in humans
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11091564
This study is looking at how fentanyl affects the brain during surgery to help doctors better manage pain and keep patients safe, especially since they can’t tell us how they feel while under anesthesia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11091564 on ClinicalTrials.gov |
What this research studies
This research investigates how fentanyl, an opioid, affects brain activity by using advanced techniques like intracranial and high-density electroencephalogram (EEG) monitoring. The goal is to develop a real-time biomarker that can measure the effects of opioids during surgery and post-operative care, which is crucial since patients cannot communicate their pain levels while under anesthesia. By understanding these brain dynamics, the research aims to improve pain management and reduce the risk of opioid dependence and overdose. This could lead to better strategies for titrating opioid dosages based on real-time brain activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for surgery who will require anesthesia and may be at risk for opioid use post-operatively.
Not a fit: Patients who are not undergoing surgery or do not require opioid pain management may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies that reduce the risk of opioid dependence and overdose in patients undergoing surgery.
How similar studies have performed: Other research has shown promise in using biomarkers for opioid effects, but this specific approach is innovative and aims to enhance real-time monitoring.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PURDON, PATRICK L. — STANFORD UNIVERSITY
- Study coordinator: PURDON, PATRICK L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.