Understanding brain signals in white matter using advanced imaging techniques
Biophysical basis of functional MRI of white matter
This study is looking at how changes in blood flow in the brain's white matter relate to brain activity, especially in people with Alzheimer's disease, to help us better understand brain function and improve ways to diagnose brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10794217 on NIH RePORTER |
What this research studies
This research investigates how blood oxygenation level dependent (BOLD) signals in white matter of the brain relate to neural activity in the cortex. By using functional magnetic resonance imaging (fMRI), the study aims to validate the presence of these signals in white matter and explore their biophysical origins. The researchers will analyze the characteristics of these signals and their correlation with brain activity, particularly in relation to conditions like Alzheimer's disease. This work could enhance our understanding of brain function and improve diagnostic methods for neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other forms of dementia.
Not a fit: Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools for Alzheimer's disease and other dementias by providing insights into brain function.
How similar studies have performed: Previous research has successfully detected BOLD signals in gray matter, but the exploration of these signals in white matter is a novel approach.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Gore, John C — Vanderbilt University Medical Center
- Study coordinator: Gore, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.