Understanding Brain Signals in Neurodevelopmental Disorders
NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy
This research explores how changes in brain signals contribute to neurodevelopmental disorders like autism and intellectual disability in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11061262 on NIH RePORTER |
What this research studies
Our brains use special signals, called NMDARs, for normal function and learning. When there are changes in the genes that make these signals, called GRIN genes, it can lead to conditions like autism, epilepsy, and intellectual disability. This project looks closely at how these genetic changes affect brain circuits at different stages of development. We want to understand why different changes can sometimes cause similar problems and how existing medicines might work differently for each person.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the underlying biology of neurodevelopmental disorders linked to GRIN gene changes, particularly in children aged 0-11 years old.
Not a fit: Patients will not receive direct treatment or benefit from participating in this basic science research, as it focuses on understanding disease mechanisms rather than clinical intervention.
Why it matters
Potential benefit: This work could lead to a better understanding of neurodevelopmental disorders and help develop more personalized and effective treatments for children affected by these conditions.
How similar studies have performed: Previous work has identified many GRIN gene variants in pediatric patients and shown that different variants respond differently to existing drugs, highlighting the need for personalized approaches.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yuan, Hongjie — Emory University
- Study coordinator: Yuan, Hongjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.