Understanding Brain Signals for Parkinson's Movement Symptoms
Oscillatory Neural Correlates of Motor Phenotypes in Parkinson Disease
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10929311
This project aims to understand the specific brain signals linked to different movement problems in people with Parkinson's disease, especially those considering deep brain stimulation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10929311 on ClinicalTrials.gov |
What this research studies
Parkinson's disease causes various movement issues like tremor, stiffness, and slow movement. While deep brain stimulation (DBS) is a common treatment, doctors currently lack clear brain markers to help decide the best DBS target for each patient's specific symptoms. This project will look closely at electrical activity in specific brain areas (subthalamic nucleus and globus pallidus internus) during DBS surgery. By studying these brain signals, we hope to find unique patterns that match different types of Parkinson's movement problems. This could lead to more personalized and effective DBS treatments in the future.
Who could benefit from this research
Good fit: Patients with Parkinson's disease who are candidates for deep brain stimulation surgery would be ideal for this type of research.
Not a fit: Patients who do not have Parkinson's disease or are not candidates for deep brain stimulation surgery would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide new brain markers to help doctors choose the most effective deep brain stimulation target for individual Parkinson's patients, leading to better symptom control.
How similar studies have performed: Preliminary studies by this team have shown initial evidence that specific brain oscillations can distinguish Parkinson's motor phenotypes, suggesting a promising approach.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INCE, NURI FIRAT — MAYO CLINIC ROCHESTER
- Study coordinator: INCE, NURI FIRAT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.