Understanding Brain Signals for Learning and Memory
Spatial, temporal, and context-dependent features of GPCR-mediated protein kinase A activity
This research aims to understand how brain signals, like acetylcholine, control cell activity in the hippocampus, a brain area important for learning and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11123159 on NIH RePORTER |
What this research studies
Our brains use special chemical messengers, called neuromodulators, to communicate and control how our cells work, especially in areas like the hippocampus that are vital for learning and memory. This project explores how one important messenger, acetylcholine, precisely directs the activity of a key protein called PKA within brain cells. We want to discover exactly where, when, and under what conditions this activity happens, as these details are crucial for how our brains form new connections and memories. This work uses both brain tissue slices and live mice to observe these intricate processes.
Who could benefit from this research
Good fit: Patients interested in the fundamental mechanisms of brain function, learning, and memory, particularly those with neurological or psychiatric conditions, may find this research relevant to future advancements.
Not a fit: Patients seeking immediate clinical trials or direct treatment options will not find direct benefit from this foundational laboratory research.
Why it matters
Potential benefit: This foundational knowledge could help us better understand and potentially develop new treatments for conditions affecting learning, memory, and overall brain function.
How similar studies have performed: This project builds upon existing knowledge that certain brain signals affect PKA activity and synaptic plasticity, but it explores the precise spatial, temporal, and context-dependent features in a novel way.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Chen, Yao — Washington University
- Study coordinator: Chen, Yao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.