Understanding Brain Signals for Learning and Memory
Phosphodiesterases govern nuclear cAMP signaling for gene expression
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11088920
This research explores how tiny signals inside brain cells are controlled to help us learn and remember.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11088920 on ClinicalTrials.gov |
What this research studies
Our brains rely on complex signals within cells to form memories and learn new things. This project looks at how specific enzymes, called phosphodiesterases (PDEs), manage a crucial signal molecule, cAMP, inside brain cells, especially in the part of the brain important for memory. We want to understand how these PDEs control cAMP levels both at the cell's surface and deep inside its control center, the nucleus. By understanding this process, particularly how certain brain receptors influence these signals, we hope to uncover new ways to support learning and memory. Previous findings suggest that medicines that block PDE4 enzymes can improve learning and memory, which makes this area very promising.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals experiencing challenges with learning and memory in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies for conditions affecting learning and memory, such as Alzheimer's disease or age-related cognitive decline.
How similar studies have performed: Studies in both animals and humans have shown that drugs targeting PDE4 enzymes can improve learning and memory, suggesting a promising direction for this research.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIANG, YANG KEVIN — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: XIANG, YANG KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.