Understanding brain signal disruptions related to psychosis in monkeys
Linking disruptions in state representation processes to neural signal impairment in nonhuman primates
This study looks at how changes in brain signals affect thinking and decision-making in macaque monkeys, helping us learn more about the brain's role in conditions like psychosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11109962 on NIH RePORTER |
What this research studies
This research investigates how disruptions in brain signals affect cognitive processes in nonhuman primates, specifically macaques. By temporarily inducing brain dysfunction similar to psychosis in humans, researchers will analyze how these changes impact the brain's ability to estimate, maintain, and learn states. The study involves training monkeys on tasks that require cognitive control and decision-making, while recording their neural activity to understand the underlying biological mechanisms. The goal is to link these neural disruptions to computational errors that may inform our understanding of psychosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20 who may be experiencing abnormal brain function or symptoms related to psychosis.
Not a fit: Patients outside the age range of 12-20 or those without signs of brain dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for psychosis and related disorders in humans.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding brain dysfunctions related to psychiatric conditions.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Chafee, Matthew V — University of Minnesota
- Study coordinator: Chafee, Matthew V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.