Understanding Brain Receptors in Alzheimer's, Autism, and Mood Disorders
Structure and Function of native kainate-type ionotropic glutamate receptor complexes
['FUNDING_OTHER'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11144979
This work explores how certain brain receptors, called kainate receptors, function and contribute to conditions like Alzheimer's disease, autism, and mood disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11144979 on ClinicalTrials.gov |
What this research studies
We want to learn more about kainate receptors, which are important for how brain cells communicate and are involved in memory and learning. These receptors are found throughout the brain, and when they don't work correctly, it can lead to various brain conditions. Our goal is to uncover the detailed structure and function of these receptors and how other molecules in the brain influence them. By understanding these basic mechanisms, we hope to find new ways to help people with these challenging conditions.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals living with or at risk for Alzheimer's disease, autism spectrum disorder, major depression, and other mood disorders.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not receive direct benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this fundamental understanding could lead to the development of new medications or treatments for neurological and psychiatric conditions linked to these brain receptors.
How similar studies have performed: While kainate receptors are known to be important, their exact molecular mechanisms are not well understood, making this a novel and foundational area of exploration.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAJIMA, NAMI — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: TAJIMA, NAMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Autistic Disorder