Understanding Brain Problems in Lupus and Finding New Treatments
Antibody-triggered mouse models of neuropsychiatric lupus: heterogeneity, mechanisms and therapeutic approaches
This project aims to understand how certain antibodies cause brain issues like memory problems, anxiety, and depression in lupus, and to discover new ways to help patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11113402 on NIH RePORTER |
What this research studies
We are developing advanced mouse models that closely resemble the brain problems seen in people with neuropsychiatric lupus. Our goal is to understand how specific antibodies enter the brain and lead to symptoms such as memory loss, anxiety, depression, and fatigue. We will also explore how different brain cells interact and contribute to inflammation, and test new treatment strategies, including those targeting specific immune pathways. This work is closely connected to ongoing studies with patients to ensure our findings are relevant to human disease.
Who could benefit from this research
Good fit: Patients with neuropsychiatric lupus who experience symptoms like cognitive impairment, anxiety, depression, or fatigue may eventually benefit from this research.
Not a fit: Patients whose lupus does not involve brain-related symptoms or who have conditions unrelated to neuropsychiatric lupus may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of neuropsychiatric lupus and the development of new, more effective treatments for brain-related symptoms.
How similar studies have performed: Researchers have successfully developed initial models of neuropsychiatric lupus, and this work builds upon those foundations to explore new mechanisms and therapeutic approaches.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Diamond, Betty — Feinstein Institute for Medical Research
- Study coordinator: Diamond, Betty
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.