Understanding Brain Pathways to Overcome Fear
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala Pathways
This work helps us understand how specific brain circuits control fear and fear memories, especially for conditions like PTSD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-11120830 on NIH RePORTER |
What this research studies
Many people with fear-related conditions like PTSD find it hard to let go of frightening memories, leading to ongoing fear. To create better treatments, we need to learn more about the brain's natural ways of stopping and forgetting fear. This project uses advanced techniques to look closely at specific brain cells and pathways, particularly in areas like the amygdala, prefrontal cortex, and hippocampus, which are important for managing fear. By mapping these circuits, we hope to uncover how the brain inhibits fear and helps us overcome scary experiences.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals living with fear-related disorders, such as Post-Traumatic Stress Disorder (PTSD), who might benefit from future treatment advancements.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to new, more targeted therapies for fear-related disorders by identifying the specific brain mechanisms involved.
How similar studies have performed: This project is a competitive renewal, building upon prior work that has already begun to identify specific cell types and their roles in fear and fear extinction pathways.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Ressler, Kerry J. — Mclean Hospital
- Study coordinator: Ressler, Kerry J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.