Understanding brain pathways affected by aging and Alzheimer's disease
Mapping the vulnerable locus coeruleus pathways in aging and AD
This study looks at how aging and Alzheimer's disease affect certain brain pathways in mice, helping us understand why some parts of the brain are more likely to get damaged, which could lead to new ways to treat the disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10913512 on NIH RePORTER |
What this research studies
This research investigates how specific brain pathways, particularly those connected to the locus coeruleus, are impacted by aging and Alzheimer's disease (AD). By examining the connectivity and sensitivity of these pathways in both aging and AD model mice, the research aims to identify why certain brain regions are more vulnerable to degeneration. The study employs advanced techniques to analyze neuronal populations and their connections, providing insights into the mechanisms of AD progression. This could lead to a better understanding of the disease and potential targets for future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline or diagnosed with Alzheimer's disease, particularly those in the early stages.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting vulnerable brain pathways.
How similar studies have performed: Previous research has shown promise in understanding brain connectivity in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Chung, Kwanghun — Massachusetts Institute of Technology
- Study coordinator: Chung, Kwanghun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.