Understanding brain networks related to cognitive aging in monkeys
Prefrontal-cingulate functional networks in aging monkeys: neural circuit substrates of cognitive aging
This study looks at how getting older affects important parts of the brain that help with thinking and decision-making, using special brain scans on monkeys to see how their brain activity changes over time, which could help us understand more about memory issues like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10726860 on NIH RePORTER |
What this research studies
This research investigates how aging affects the brain's prefrontal and cingulate areas, which are crucial for cognitive functions. By using advanced imaging techniques like functional MRI, the study aims to explore the changes in neural circuits and network dynamics as monkeys age. The goal is to understand the relationship between these changes and cognitive decline, which could provide insights into conditions like Alzheimer's disease. This research will help identify the underlying mechanisms of cognitive aging and how they manifest in brain activity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be older adults experiencing cognitive changes or those at risk for neurodegenerative diseases.
Not a fit: Patients who are not experiencing cognitive decline or are younger than 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive decline in aging populations.
How similar studies have performed: Previous studies have shown promising results in understanding brain network dynamics in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Medalla, Maria — Boston University Medical Campus
- Study coordinator: Medalla, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.