Understanding brain network mechanisms in Fragile X Syndrome
Official title: Network mechanisms underlying core behavioral features in Fragile X Syndrome
Funded at University of Oklahoma · NIH-10900221 · Data updated 2026-11-12
This study is looking at how the brains of people with Fragile X Syndrome connect and work together, hoping to find out more about the challenges they face with thinking and behavior, so we can create better support and treatments for them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma NIH-funded |
| Lab location | 1 site (Norman, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 1F31HD113221-01A1 |
| Project ID | NIH-10900221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome, particularly those exhibiting cognitive impairments and behavioral challenges.
✕Less likely to help
Patients without a diagnosis of Fragile X Syndrome or those who do not exhibit cognitive or behavioral issues related to the condition may not benefit from this research.
What this research studies
This research investigates the brain connectivity patterns in individuals with Fragile X Syndrome (FXS), a genetic condition that often leads to intellectual disabilities and autism spectrum disorder. By using electroencephalography (EEG), the study aims to identify specific disruptions in brain networks that relate to cognitive impairments and behavioral features associated with FXS. The goal is to differentiate between cognitive control issues and behavioral symptoms like sensory hypersensitivity and anxiety, which could lead to targeted interventions for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted treatments for individuals with Fragile X Syndrome, enhancing their cognitive and behavioral outcomes.
How similar studies have gone: Previous research has shown promise in understanding brain connectivity in neurodevelopmental disorders, suggesting that this approach could yield valuable insights for Fragile X Syndrome as well.
Where this research is happening
-
University of Oklahoma
Norman, United States Active
Researchers
- Principal investigator: Norris, Jordan — University of Oklahoma
- Study coordinator: Norris, Jordan
Related research
Other NIH-funded projects on the same topics.
-
Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
-
Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
-
Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
-
Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
-
Brain research on Fragile X Syndrome to improve therapies
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.