Understanding brain network issues in Down syndrome related to Alzheimer's disease
Septhohippocamal connectome dysfunction in Down syndrome associated with Alzheimer’s disease pathophysiology
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10595384
This study is looking at how Down syndrome might change the brain and make people more likely to develop Alzheimer's disease earlier, and it's for anyone interested in understanding how we can help those with Down syndrome stay mentally healthy as they age.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10595384 on ClinicalTrials.gov |
What this research studies
This research investigates how Down syndrome (DS) affects brain networks and increases the risk of developing Alzheimer's disease (AD) at an early age. By studying both animal models and human cells, the research aims to uncover the molecular and cellular changes that lead to cognitive decline in individuals with DS. The team will analyze specific brain circuits that are crucial for memory and executive function, comparing findings from trisomic mice and human induced neurons derived from individuals with DS and AD. The ultimate goal is to identify potential targets for interventions that could delay or prevent the onset of dementia in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Down syndrome, particularly those who are in early midlife and may be at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding the connections between Down syndrome and Alzheimer's disease, but this specific approach is novel and aims to fill critical knowledge gaps.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GINSBERG, STEPHEN D — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: GINSBERG, STEPHEN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease pathology