Understanding brain network changes related to emotional disorders
Official title: HCP-2.0: Ascertaining Network Mechanisms and Analytics of Emotional Dysfunction (HARMONY)
Funded at University of Pennsylvania · NIH-10930150 · Data updated 2026-11-12
This study is looking at how anxiety and similar emotional issues are linked to changes in the brain, and it’s for both teens and adults, whether they have these challenges or not, to help us understand how our brains affect our feelings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $778,117 |
| NIH project number | 5R01MH132962-02 |
| Project ID | NIH-10930150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and adults experiencing anxiety or related emotional disorders.
✕Less likely to help
Patients without emotional disorders or those who do not fall within the specified age range may not benefit from this research.
What this research studies
This research investigates how emotional dysfunctions, particularly anxiety and related disorders, are connected to changes in brain networks. By analyzing data from various studies, including brain imaging and cognitive assessments, the research aims to identify specific patterns and subtypes of symptoms in both adolescents and adults. The study will involve a large group of participants, including those with emotional disorders and healthy individuals, to better understand the underlying brain mechanisms. Advanced computational techniques will be used to process and analyze the data, providing insights into the relationship between brain function and emotional health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted treatments for emotional disorders.
How similar studies have gone: Previous research utilizing similar approaches has shown promise in understanding brain connectivity and its relation to mental health conditions.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Sheline, Yvette I — University of Pennsylvania
- Study coordinator: Sheline, Yvette I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.