Understanding brain metabolism and blood flow issues in Alzheimer's disease
Impaired cerebral metabolism and blood flow by neuronal and astrocytic dysfunctions in Alzheimer's disease
This study is looking at how problems with brain cells affect energy use and blood flow in people with Alzheimer's, hoping to find new ways to help improve brain health and memory.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11093427 on NIH RePORTER |
What this research studies
This research investigates how dysfunctions in neurons and astrocytes affect brain metabolism and blood flow in Alzheimer's disease. By using a combination of advanced imaging techniques, the study aims to identify the sequence of events that lead to cognitive decline in patients. The approach focuses on understanding the relationship between reduced glucose metabolism, insulin resistance, and the resulting impact on brain health. Patients may benefit from insights that could lead to new treatment strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to study brain function in Alzheimer's, suggesting that this approach may yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Herman, Peter — Yale University
- Study coordinator: Herman, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.