Understanding brain mechanisms in treating obesity and binge-eating disorder
Neurocognitive fMRI Mechanisms of CBT and Lisdexamfetamine Outcomes in Obesity and BED
This study is looking at how therapy and a specific medication can help people with obesity and binge-eating disorder by checking changes in brain activity before and after treatment, so if you're dealing with these challenges, your participation could help find better ways to support others like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10475710 on NIH RePORTER |
What this research studies
This research investigates how cognitive behavioral therapy (CBT) and the medication lisdexamfetamine (LDX) affect individuals with obesity and binge-eating disorder (BED). By using functional MRI (fMRI), the study aims to identify brain activity patterns before and after treatment, focusing on areas related to food preoccupation, cognitive control, and emotional responses. Participants will undergo three different treatment conditions over 12 weeks, allowing researchers to assess the effectiveness of each approach and how they work together. The findings could provide valuable insights into the best treatment strategies for this challenging population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with obesity and binge-eating disorder.
Not a fit: Patients who do not have obesity or binge-eating disorder may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for individuals struggling with obesity and binge-eating disorder.
How similar studies have performed: Previous research has shown promising results using similar approaches in understanding treatment mechanisms for obesity and eating disorders.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Potenza, Marc N — Yale University
- Study coordinator: Potenza, Marc N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.