Understanding brain mechanisms behind hypo/mania in bipolar disorder
Elucidating neural mechanisms of hypo/mania using theta burst stimulation
This study is looking at how certain brain activities affect mood swings in people with bipolar disorder, and it uses a special technique to see if changing these activities can help improve feelings and behaviors, with the hope of finding better treatments for the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11071979 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms that contribute to hypo/mania in individuals with bipolar disorder. It focuses on how certain brain activities, particularly in the left ventrolateral prefrontal cortex, relate to impulsivity and reward sensitivity. Using a technique called theta burst stimulation, the study aims to modulate brain activity to observe changes in mood and behavior. By understanding these mechanisms, the research seeks to inform new treatment strategies for bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have a history of bipolar disorder or exhibit mild to moderate symptoms.
Not a fit: Patients with severe bipolar disorder or those who do not meet the age criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved interventions for managing hypo/mania in bipolar disorder.
How similar studies have performed: Previous research has shown promise in using brain stimulation techniques to influence mood disorders, suggesting potential for success in this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Phillips, Mary Louise — University of Pittsburgh at Pittsburgh
- Study coordinator: Phillips, Mary Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.