Understanding brain lipid changes in aging and Lewy body dementia using advanced imaging techniques
Official title: Mapping Brain Lipid Architecture in Aging, LBD and T Cell Therapy using novel Imaging Mass Spectrometry
Funded at University of Florida · NIH-10991070 · Data updated 2026-11-12
This study is looking at how fats in the brain might affect the progression of Lewy body dementia and Parkinson's disease, using a special imaging technique to see where these fats are located, with the hope of finding new ways to help slow down these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $400,707 |
| NIH project number | 1R21AG089638-01 |
| Project ID | NIH-10991070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lewy body dementia or Parkinson's disease, particularly those experiencing cognitive decline.
✕Less likely to help
Patients with other types of dementia or neurological disorders unrelated to Lewy body pathology may not benefit from this research.
What this research studies
This research investigates the role of lipids in the progression of Lewy body dementia (LBD) and Parkinson's disease (PD) by utilizing a novel imaging mass spectrometry technique. The study aims to visualize and quantify lipid distribution in the brain, which may provide insights into how these lipids contribute to neurodegeneration. By examining the lipid architecture over time, researchers hope to identify potential therapeutic targets and understand the underlying mechanisms of these diseases. Patients may benefit from this research through the development of new treatment strategies that could slow disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow the progression of Lewy body dementia and improve patient outcomes.
How similar studies have gone: Previous research has shown promising results in using lipid modulation as a therapeutic approach in neurodegenerative diseases, indicating potential for success in this novel application.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Vedam-Mai, Vinata — University of Florida
- Study coordinator: Vedam-Mai, Vinata
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.