Understanding brain issues related to a specific muscular dystrophy
Synaptic dysfunction in models of dystroglycanopathy
This study is looking at how a protein called Dystroglycan, which helps the brain work properly, is affected in a type of muscular dystrophy, and it aims to find ways to fix problems with brain communication that might help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11062529 on NIH RePORTER |
What this research studies
This research investigates how a protein called Dystroglycan, which is important for brain function, is affected in a type of muscular dystrophy known as dystroglycanopathy. The study uses mouse models to explore the role of Dystroglycan in the development and function of inhibitory synapses in the brain, which are crucial for proper communication between nerve cells. Researchers will examine the cellular mechanisms involved and test whether these synaptic defects can be corrected, potentially identifying effective treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dystroglycanopathy, particularly those experiencing neurological symptoms.
Not a fit: Patients without dystroglycanopathy or those who do not exhibit neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve neurological function in patients with dystroglycanopathy.
How similar studies have performed: Previous research has shown promising results in understanding synaptic dysfunction in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Wright, Kevin — Oregon Health & Science University
- Study coordinator: Wright, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.