Understanding brain injury in children after cardiac arrest
Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrest
This study is looking at how brain injuries happen in kids who have had a cardiac arrest, and it aims to find the best blood pressure levels to help protect their brains and improve their recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10912825 on NIH RePORTER |
What this research studies
This research investigates how brain injuries occur in children who have experienced cardiac arrest, focusing on the role of cerebral autoregulation in maintaining blood flow to the brain. By measuring blood flow and using advanced MRI techniques, the study aims to identify the optimal blood pressure levels that protect the brain from further injury. The goal is to improve post-cardiac arrest care and reduce the risk of long-term neurological disabilities in pediatric patients. Participants will undergo non-invasive imaging to assess their brain health and blood flow dynamics.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have survived a cardiac arrest.
Not a fit: Patients who have not experienced cardiac arrest or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that minimize brain injury and enhance recovery outcomes for children after cardiac arrest.
How similar studies have performed: Previous research has shown promising results in understanding brain injury mechanisms in pediatric populations, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kirschen, Matthew P — Children's Hosp of Philadelphia
- Study coordinator: Kirschen, Matthew P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.