Understanding brain injury effects on nerve cell development after premature birth
Mechanisms of Oligodendrocyte and Axonal Abnormalities After Perinatal Brain Injury
This study looks at how brain injuries that happen around the time of birth can affect the growth of important brain cells, which might help us understand why some children develop conditions like cerebral palsy or learning delays.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10928719 on NIH RePORTER |
What this research studies
This research investigates how brain injuries that occur during the perinatal period affect the development of oligodendrocytes and axons, which are crucial for proper brain function. By using animal models, the study examines the cellular mechanisms that lead to delayed maturation of oligodendrocyte progenitor cells and abnormal myelination, which can result in serious conditions like cerebral palsy and cognitive delays. The researchers aim to uncover the underlying pathophysiology of these injuries to better understand their long-term impacts on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children who have experienced perinatal brain injuries or are at risk for conditions related to white matter injury.
Not a fit: Patients who have not experienced perinatal brain injuries or related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for children affected by brain injuries due to premature birth.
How similar studies have performed: Previous research has shown promising results in understanding the cellular mechanisms of brain injury and myelination, indicating that this approach has potential for significant advancements.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Vittorio Gallo, Vittorio Gallo Vittorio Gallo — Seattle Children's Hospital
- Study coordinator: Vittorio Gallo, Vittorio Gallo Vittorio Gallo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.