Understanding Brain Inflammation and Genetic Factors in Male Autism Risk
Neuroinflammation, Epigenetics and Male Vulnerability
This research explores how brain inflammation and genetic changes during early development might make males more likely to develop conditions like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11097388 on NIH RePORTER |
What this research studies
This research explores how the developing brain, especially in males, might be more susceptible to certain changes during important growth periods. We are looking at how brain inflammation and genetic factors, known as epigenetics, could play a role in increasing the risk for neurodevelopmental conditions such as autism. Specifically, we are interested in how immune cells in the brain, like microglia and mast cells, influence brain development and how these processes might differ between sexes. Understanding these early life events could help us find new ways to support healthy brain development in children.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but its findings could eventually benefit children at risk for or diagnosed with neurodevelopmental disorders like autism.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or lessen the impact of neurodevelopmental disorders, particularly in males.
How similar studies have performed: While the specific combination of neuroinflammation, epigenetics, and male vulnerability in brain development is a novel focus, research on individual aspects like neuroinflammation in autism and critical periods in brain development has shown promise.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Mccarthy, Margaret M. — University of Maryland Baltimore
- Study coordinator: Mccarthy, Margaret M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.