Understanding brain inflammation and cognitive issues in young adults with HIV who use cannabis
Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users
This study is looking at how HIV and cannabis use impact brain inflammation and thinking skills in young adults, and it aims to find out how these factors work together to affect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10837039 on NIH RePORTER |
What this research studies
This research investigates how HIV infection and cannabis use affect brain inflammation and cognitive function in young adults. It focuses on understanding the mechanisms behind HIV-associated neurocognitive disorders (HAND) and how cannabis may influence these processes. By examining cerebrospinal fluid and using advanced techniques like single-cell RNA sequencing, the study aims to identify potential biomarkers and therapeutic targets. Participants may undergo assessments to evaluate cognitive function and inflammation levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults under 21 years old who are HIV-positive and use cannabis.
Not a fit: Patients who are not HIV-positive or do not use cannabis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management strategies for cognitive impairments in young adults living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the effects of cannabis on inflammation, but this specific approach to HAND in young adults is relatively novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Murdoch, David Martin — Duke University
- Study coordinator: Murdoch, David Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.