Understanding Brain Inflammation After Stroke
PERK dependent mechanisms of neuroinflammation
This research explores how specific cell processes contribute to brain inflammation and damage after an ischemic stroke, hoping to find new ways to protect brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11089479 on NIH RePORTER |
What this research studies
Ischemic stroke, a condition where blood flow to the brain is blocked, can cause significant long-term challenges. Currently, there are limited treatment options available to help patients recover. This project looks closely at how brain cells respond to stroke, specifically focusing on a process called endoplasmic reticulum (ER) stress, which leads to inflammation and cell death. We are particularly interested in a protein called PERK and how it affects inflammation in important brain cells like astrocytes and microglia. By understanding these mechanisms, we hope to uncover new strategies to reduce brain damage and improve recovery after a stroke.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals who have experienced or are at risk of ischemic stroke.
Not a fit: Patients whose conditions are unrelated to ischemic stroke or neuroinflammation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new treatments that reduce brain inflammation and protect brain cells, ultimately improving recovery for stroke patients.
How similar studies have performed: While the role of ER stress in stroke is known, this specific focus on PERK and JAK1 signaling in astrocytes and microglia represents a novel approach to understanding and potentially treating neuroinflammation after stroke.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Meares, Gordon P. — Ohio State University
- Study coordinator: Meares, Gordon P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.