Understanding Brain Immunity and Drainage in Alzheimer's Disease
Neuroimmunology of AD and CAA with focus on innate immunity and lymphatics
This work explores how the brain's immune system and waste removal pathways contribute to Alzheimer's disease and a related condition called cerebral amyloid angiopathy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11136251 on NIH RePORTER |
What this research studies
We are looking closely at the complex ways the brain's immune cells, called microglia and macrophages, interact with the lymphatic system that drains fluid from the brain. Our goal is to understand how these systems work together, or sometimes fail, in people with Alzheimer's disease and cerebral amyloid angiopathy. By focusing on these natural clearance pathways, we hope to uncover new ways to help the brain remove harmful protein buildup. This deeper understanding could lead to new treatments that improve brain health and reduce cognitive decline.
Who could benefit from this research
Good fit: This foundational research is for individuals interested in the underlying biological mechanisms of Alzheimer's disease and cerebral amyloid angiopathy.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to new treatment approaches that enhance the brain's natural ability to clear harmful proteins, potentially slowing or preventing the progression of Alzheimer's disease and cerebral amyloid angiopathy.
How similar studies have performed: While the specific combination of innate immunity and lymphatic drainage in AD/CAA is a growing area, previous research has shown promise in targeting individual components of these systems.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Kipnis, Jonathan — Washington University
- Study coordinator: Kipnis, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.