Understanding Brain Immune Cells in Small Vessel Disease and Memory Problems
Role of Microglia in Cerebral Small Vessel Disease (CSVD)/Vascular Cognitive Impairment (VCI)
This research explores how special immune cells in the brain contribute to memory and thinking problems caused by small vessel damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11098631 on NIH RePORTER |
What this research studies
Small vessel disease in the brain can lead to memory and thinking problems, and we believe that specialized immune cells called microglia play a key role. Our team is using a unique mouse model that closely resembles human small vessel disease to understand how these microglia contribute to the condition. We will look at the genetic activity of these cells and test if a treatment that reduces their numbers can improve brain health, memory, and thinking abilities. Advanced brain imaging and genetic tools will help us observe these changes.
Who could benefit from this research
Good fit: This research is relevant for individuals experiencing memory and thinking problems due to cerebral small vessel disease.
Not a fit: Patients without cerebral small vessel disease or vascular cognitive impairment would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect brain health and improve memory for people living with vascular cognitive impairment.
How similar studies have performed: While the specific mouse model is novel, the concept of targeting brain immune cells has shown promise in other neurological conditions.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Weinstein, Jonathan R — University of Washington
- Study coordinator: Weinstein, Jonathan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.