Understanding Brain Health in Young People at Risk for Type 2 Diabetes

Brain Health Across the Metabolic Continuum in Youth at Risk for T2D

NIH-funded research Washington University · NIH-11142556

This project looks at how brain health changes in young people who are at risk for developing type 2 diabetes.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWashington University NIH-funded
Lab location1 site (Saint Louis, United States)
Project IDNIH-11142556 on NIH RePORTER

What this research studies

We know that type 2 diabetes can affect brain health in adults, sometimes increasing the risk for conditions like Alzheimer's disease. With more young people developing type 2 diabetes, we want to understand if these brain changes also happen earlier in life and how they progress. Our work involves looking closely at the brain health of young individuals who are at different stages of risk for type 2 diabetes, from those with obesity to those already diagnosed. By doing this, we hope to discover the specific factors that influence brain structure and function in these young people.

Who could benefit from this research

Good fit: Ideal candidates would be young individuals across a range of body weights and metabolic health, including those with obesity or type 2 diabetes.

Not a fit: Patients who are not in the youth age range or do not have risk factors for type 2 diabetes may not directly benefit from this specific research.

Why it matters

Potential benefit: If successful, this work could help us identify early signs of brain complications in youth with or at risk for type 2 diabetes, leading to better prevention or treatment strategies.

How similar studies have performed: While brain complications in adult type 2 diabetes are recognized, understanding these effects specifically in youth and across the metabolic spectrum is a relatively new area of focus.

Where this research is happening

Saint Louis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Adult-Onset Diabetes MellitusAlzheimer's disease risk
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.