Understanding Brain Health in People with HIV and Fatty Liver Disease
Impact of NAFLD on Metabolic Brain Function via CEST MRI in HIV-Positive Individuals
This research explores how fatty liver disease might affect brain health in people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11132946 on NIH RePORTER |
What this research studies
Many people living with HIV also develop non-alcoholic fatty liver disease (NAFLD), which can be influenced by both the virus and their medications. We believe that people with HIV and NAFLD might experience more changes in their brain, such as issues with the blood-brain barrier and metabolism, which could lead to poorer cognitive function. To explore this, we will use advanced, non-invasive MRI scans to look for signs of brain injury and changes in brain function. Our goal is to understand these connections better, especially in older individuals.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be people living with HIV who also have non-alcoholic fatty liver disease.
Not a fit: Patients without HIV or non-alcoholic fatty liver disease would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could help us understand why some people with HIV and NAFLD experience brain health issues, potentially leading to earlier detection or new ways to protect brain function.
How similar studies have performed: This research uses state-of-the-art MRI techniques and develops a novel AI-based approach, building on existing knowledge while exploring new methods.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Uddin, Md Nasir — University of Rochester
- Study coordinator: Uddin, Md Nasir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.