Understanding brain health in adults with perinatally acquired HIV
Official title: Accelerated Rosette Trajectories- Based 5D MR Spectroscopic Imaging AND MR Imaging of Myelin Fraction in Perinatally HIV-Infected Adults
Funded at University of California Los Angeles · NIH-10924712 · Data updated 2026-11-12
This study is looking at how HIV impacts the brains of adults who were born with the virus and have been on treatment for a long time, using special imaging to see if their brain health can be improved with better therapies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $415,876 |
| NIH project number | 1R21NS134488-01A1 |
| Project ID | NIH-10924712 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who were infected with HIV at birth and are currently receiving antiretroviral therapy.
✕Less likely to help
Patients who were not infected with HIV or those who do not have a history of perinatal HIV infection may not benefit from this research.
What this research studies
This research investigates how HIV affects the developing brain in adults who were infected at birth and have been on antiretroviral therapy for a long time. It uses advanced imaging techniques to measure myelin content in the brain, which is crucial for healthy brain function. By employing a novel five-dimensional imaging method, the study aims to identify brain abnormalities and assess the effectiveness of current treatments. This could lead to better therapeutic strategies for preserving brain health in these individuals.
Why it matters
Potential benefit: If successful, this research could improve treatment approaches for brain health in adults with perinatally acquired HIV.
How similar studies have gone: Previous research has shown success in using advanced imaging techniques to study brain health in HIV-infected populations, indicating a promising approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Thomas, Michael Albert — University of California Los Angeles
- Study coordinator: Thomas, Michael Albert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.