Understanding brain function changes in a mouse model of a genetic condition linked to schizophrenia
Microcircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletion
This study looks at how a missing piece of DNA affects memory and learning in mice, which could help us understand why some people with a specific genetic condition, known as 22q11.2 deletion syndrome, have trouble with thinking and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10887461 on NIH RePORTER |
What this research studies
This research investigates how a specific genetic deletion affects brain function related to memory and learning in a mouse model. By using advanced imaging techniques, the study examines the activity of brain cells in the hippocampus, which is crucial for forming memories. The researchers aim to identify the biological mechanisms that lead to cognitive deficits observed in individuals with the 22q11.2 deletion syndrome, a known risk factor for schizophrenia. Insights gained from this research could help in understanding the underlying causes of cognitive impairments associated with this genetic condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with 22q11.2 deletion syndrome or those with a family history of schizophrenia.
Not a fit: Patients without the 22q11.2 deletion syndrome or those not affected by cognitive deficits related to schizophrenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognitive function in patients with 22q11.2 deletion syndrome and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding cognitive deficits in similar genetic models, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Losonczy, Attila — Columbia University Health Sciences
- Study coordinator: Losonczy, Attila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.