Understanding brain fluid circulation in Alzheimer's-related dementias
Quantitative imaging of choroid plexus function and neurofluid circulation in Alzheimer's Disease Related Dementia
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11136248
This work aims to improve brain imaging to better understand how fluid moves in the brain and how it might be linked to Alzheimer's disease and related dementias.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11136248 on ClinicalTrials.gov |
What this research studies
We are working to make brain imaging more precise to see how a part of your brain called the choroid plexus works and how brain fluid flows. This is important because the choroid plexus produces the fluid that cleans your brain, and problems with this fluid flow are connected to memory disorders. By using advanced MRI techniques and smart computer programs, we hope to get a clearer picture of these processes in people with Alzheimer's-related dementias. This could help us understand why these conditions develop and how they affect the brain.
Who could benefit from this research
Good fit: Ideal candidates for future related studies would likely be adults aged 21 and older who have been diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients whose conditions are not related to Alzheimer's disease or brain fluid circulation issues may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to detect early changes in the brain related to Alzheimer's disease and related dementias, potentially guiding future treatments.
How similar studies have performed: Preliminary data from this group has shown promising results in measuring choroid plexus activity in healthy adults and those with dementia, suggesting the approach is viable.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DONAHUE, MANUS J — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: DONAHUE, MANUS J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease