Understanding brain fiber structures using advanced imaging techniques
Bridging Diffusion MRI and Chemical Tracing for Validation and Inference of Fiber Architectures
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10764197
This study is looking at the brains of macaques to learn more about how different pathways in the brain are connected, which could help improve brain imaging techniques for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10764197 on ClinicalTrials.gov |
What this research studies
This research aims to collect and analyze a unique dataset from macaque brains using both diffusion MRI and tracer injections. By developing new algorithms, the project seeks to improve the understanding of local fiber architectures in the brain, particularly in distinguishing complex configurations like crossings and branches. The findings will provide valuable insights into brain pathways and enhance the accuracy of neuroimaging techniques. This collaborative effort combines expertise from leading institutions in diffusion MRI and anatomical studies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions that affect brain structure and function.
Not a fit: Patients with conditions unrelated to brain structure or those who do not have access to advanced imaging facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved neuroimaging techniques that enhance the diagnosis and treatment of brain disorders.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for brain analysis, indicating that this approach could yield significant insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YENDIKI, ANASTASIA — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: YENDIKI, ANASTASIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Disorders, Encephalon Diseases, Intracranial CNS Disorders