Understanding Brain Differences in Neurodevelopmental Conditions
Molecular and Cellular Mechanisms of Cerebellar Dysfunction in Neurodevelopmental disorders
This research explores how differences in a part of the brain called the cerebellum might contribute to conditions like autism and ADHD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11136976 on NIH RePORTER |
What this research studies
Many neurodevelopmental conditions, including autism and ADHD, involve challenges with movement, senses, learning, and social interactions. Our brain has a region called the cerebellum that helps with these functions, and sometimes it doesn't develop typically in people with these conditions. We are looking closely at how specific genes, like EBF3, affect the cerebellum's development and function. By understanding these molecular and cellular changes, we hope to uncover the root causes of these conditions.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals and families affected by neurodevelopmental disorders such as autism, ADHD, and conditions like HADDS.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this basic science research.
Why it matters
Potential benefit: This work could lead to a deeper understanding of neurodevelopmental disorders, potentially paving the way for new ways to help patients in the future.
How similar studies have performed: Previous discoveries, including the identification of the EBF3 gene's role in a specific neurodevelopmental syndrome, provide a strong foundation for this ongoing work.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Chao, Hsiao-Tuan — Baylor College of Medicine
- Study coordinator: Chao, Hsiao-Tuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.