Understanding brain development in children with HIV
Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence
This study looks at how starting HIV treatment early can help kids who were born with the virus develop their brains and thinking skills as they grow up, especially for those living in areas with fewer resources.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10654622 on NIH RePORTER |
What this research studies
This research investigates how early treatment for HIV affects cognitive and brain development in children who were infected perinatally. By following these children into adolescence, the study aims to assess changes in brain structure and function over time. The researchers will use advanced brain imaging techniques alongside cognitive assessments to gather comprehensive data on the participants' neurodevelopment. This study is particularly focused on children from resource-limited settings, where the impact of HIV is most severe.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0-20 who were perinatally infected with HIV and are receiving treatment.
Not a fit: Patients who were not infected with HIV or who were infected later in life may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for cognitive impairments in children living with HIV.
How similar studies have performed: Previous research has shown that longitudinal studies on neurodevelopment in HIV-infected populations can yield valuable insights, suggesting this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Van Der Kouwe, Andre Jan Willem — Massachusetts General Hospital
- Study coordinator: Van Der Kouwe, Andre Jan Willem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.