Understanding brain development disorders using brain organoids
Elucidating the molecular mechanisms behind human neurodevelopmental disorders using brain organoids
This study is looking at how certain genetic changes and environmental influences can affect brain development and function by using tiny brain-like structures made from human stem cells, with the goal of finding new ways to help people with neurodevelopmental and neuropsychiatric disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10994668 on NIH RePORTER |
What this research studies
This research investigates the underlying molecular mechanisms of neurodevelopmental and neuropsychiatric disorders by utilizing brain organoids derived from human stem cells. These organoids mimic the structure and function of human brain tissue, allowing researchers to study how genetic mutations and environmental factors disrupt normal brain development and function. By examining the neural networks within these organoids, the research aims to identify potential therapeutic targets and improve treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodevelopmental or neuropsychiatric disorders, particularly those with known genetic mutations.
Not a fit: Patients with purely environmental causes of neurodevelopmental disorders, without any genetic component, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies and improved understanding of neurodevelopmental disorders, ultimately enhancing treatment options for patients.
How similar studies have performed: Previous research using brain organoids has shown promise in modeling neurological disorders, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Novitch, Bennett G — University of California Los Angeles
- Study coordinator: Novitch, Bennett G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.