Understanding brain damage caused by nerve agents
Official title: Mechanisms of Neurodegeneration in a Nerve Agent Model
Funded at Iowa State University · NIH-11094835 · Data updated 2026-11-12
This study is looking at how being exposed to certain nerve agents can impact the brain over time, especially after experiencing seizures, and aims to find ways to help treat brain injuries caused by these exposures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $459,000 |
| NIH project number | 5R01NS133584-02 |
| Project ID | NIH-11094835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced exposure to organophosphate nerve agents and are suffering from related neurological symptoms.
✕Less likely to help
Patients who have not been exposed to organophosphate nerve agents or do not exhibit neurological symptoms may not benefit from this research.
What this research studies
This research investigates how exposure to organophosphate nerve agents affects the brain, particularly focusing on the long-term consequences of seizures induced by these agents. The study aims to uncover the molecular mechanisms behind neurodegeneration and inflammation that occur after acute exposure. By examining the interactions between specific proteins in neurons and glial cells, the researchers hope to identify potential therapeutic targets for treating brain injuries caused by nerve agents. Patients may benefit from insights that could lead to new treatments for those affected by such exposures.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for individuals suffering from long-term brain injuries caused by nerve agents.
How similar studies have gone: While the specific mechanisms being studied may be novel, previous research has shown success in identifying therapeutic targets for neurodegeneration in other contexts.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Thippeswamy, Thimmasettappa — Iowa State University
- Study coordinator: Thippeswamy, Thimmasettappa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.