Understanding brain damage and recovery in early multiple sclerosis.
Official title: Cortical Demyelination and Repair in Early Multiple Sclerosis.
Funded at Icahn School of Medicine at Mount Sinai · NIH-10945252 · Data updated 2026-11-12
This study is looking at how brain damage happens and heals in young adults with early multiple sclerosis (MS), using special MRI scans to see these changes up close, with the hope of finding better ways to treat the condition and help manage disability.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $667,644 |
| NIH project number | 1R01NS138611-01 |
| Project ID | NIH-10945252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young adults diagnosed with early multiple sclerosis who are experiencing cognitive or physical symptoms.
✕Less likely to help
Patients with advanced multiple sclerosis or those who do not have a diagnosis of multiple sclerosis may not benefit from this research.
What this research studies
This research investigates how brain lesions develop and heal in individuals with early multiple sclerosis (MS), a condition that affects young adults and can lead to significant disability. By using advanced MRI techniques, the study aims to visualize these lesions in real-time and understand the immune responses involved in their formation and repair. The goal is to uncover the relationship between these cortical lesions and the progression of disability in MS patients, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with early multiple sclerosis, potentially reducing disability progression.
How similar studies have gone: Previous research has shown promise in understanding brain lesions in multiple sclerosis, but this study aims to explore novel aspects of cortical lesion dynamics that have not been extensively tested.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Beck, Erin Savner — Icahn School of Medicine at Mount Sinai
- Study coordinator: Beck, Erin Savner
Related research
Other NIH-funded projects on the same topics.
-
Susceptibility-based MRI biomarkers for multiple sclerosis
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Mediterranean-style eating and aging in people with multiple sclerosis
This project looks at whether following a Mediterranean-style diet is linked to slower biological aging and less brain shrinkage in people living with multiple sclerosis.
-
Imaging brain energy use in multiple sclerosis with a new imaging method
A new MRI-based method will non-invasively measure how the brain uses glucose and ketones in people with multiple sclerosis.
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Astrocyte exosomes as aging biomarkers and drivers of MS progression
Researchers are testing a blood-based biomarker from astrocyte-like exosomes to understand why multiple sclerosis gets worse with age and to identify potential targets for treatment.
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Promoting brain repair in MS with a natural compound that nudges neural stem cells
A researcher is testing a natural-product–based compound that may help people with multiple sclerosis repair nerve damage by guiding brain stem cells to become neurons and myelin-producing cells.
-
Targeted B cell tolerance therapy for multiple sclerosis using Ace-DEX microparticles
A new therapy using tiny biopolymer particles given through the vein aims to retrain B cells to tolerate the immune system in people with multiple sclerosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.