Understanding brain connectivity changes in early Alzheimer's disease
Neurophysiological Basis for Functional Connectivity Changes in Early Alzheimer’s Disease
This study is looking at how early signs of Alzheimer's disease, like the presence of amyloid-β, affect brain activity and connections in mice, which could help us find ways to spot Alzheimer's earlier in people who seem healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10898658 on NIH RePORTER |
What this research studies
This research investigates how early Alzheimer's disease affects brain connectivity and activity. It focuses on individuals who are cognitively normal but show signs of amyloid-β, a biomarker for Alzheimer's. By using advanced imaging techniques, the study aims to understand how amyloid-β influences neuronal and glutamate activity at different scales in mouse models. The findings could help identify early biomarkers for Alzheimer's before clinical symptoms appear.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are cognitively normal but have positive amyloid-β biomarkers.
Not a fit: Patients with advanced Alzheimer's disease or those without amyloid-β biomarkers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using biomarkers like amyloid-β for early detection of Alzheimer's, suggesting this approach could be effective.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Cover, Christopher Gregory — University of Pittsburgh at Pittsburgh
- Study coordinator: Cover, Christopher Gregory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.